The station building is located above the tracks, and accessibility to and from the platforms is provided by escalators as well as lifts.

Mejiro is one of the Yamanote Line's smaller stations, situated between the bustling Ikebukuro and the relatively quiet Takadanobaba.

The ticket gate emerges onto Mejiro-dori with the co-ed campus of Gakushuin University and the Mejiro Elementary School to the right, and a busy row of shops and restaurants to the left.

The streets to the west, away from the Yamanote loop, feature a mix of typical apartment buildings spanning a few decades, and some very opulent designer houses with luxury vehicles in their garages.

By looking straight ahead from Mejiro Station's main exit, one can see well into the distance toward Ikebukuro's monument-like garbage processing center and the towering Sunshine 60 building.