He experimental with digital fine art prints in the 1980s that are in 30 museum collections worldwide, circumglobal cyberangel flights honoring Rembrandt in 1989 and in 2019.

His integration of art and science had its origins in his childhood summers in the Catskill Mountains studying the creatures of the forests and ponds and making drawings and paintings of them in their natural habitats and in imaginary worlds.

In 1965, he began his doctoral studies at New York University excited about the artistic possibilities of digital technologies when the first computer plotter arrived at NYU.

[9] Digitized Homage to Rembrandt: Jacob's Dream (1986–87), an etching and aquatint from a computer-generated image, is in the collection of the Metropolitan Museum of Art.

[10] A series of eight artworks linking the four corners of United States was created by Alexenberg as the official artist of Miami’s Centennial in 1996 when he was dean at New World School of the Arts.

The explanatory catalog of the exhibition was coupled by the artist’s statement in Leonardo: Journal of the International Society for the Arts, Sciences and Technology[15] (vol.

Millions throughout North America watched the cyberangel return from its circumglobal flight over the major TV networks' broadcasts from New York .

[7] LightsOROT[18][19] is an interactive electronic art environment created by Mel Alexenberg in collaboration with Otto Piene and his colleagues and graduate students at MIT Center for Advanced Visual Studies to explore the spiritual dimensions of the digital age.