Melchizedek II (Georgian: მელქისედეკ I, romanized: melkisedek' I; died c. 1553) was the Catholicos Patriarch of Georgia in the years of c. 1538–1541[1] or in the periods of 1528-1529, 1540-1545, and 1548-1552.
[2] He was a son of King Constantine II of Kartli by his wife Tamar.