[4] As an actress, Rivers has had roles in television shows including Beverly Hills 90210, Silk Stalkings and The Comeback.

In 1998, she also appeared in the sci-fi/comedy made-for-television movie Men in White and in the 1999 film The Big Tease, a comedy directed by Kevin Allen starring Craig Ferguson.

Featured videos that have garnered the most views featured comedians Kathy Griffin, Sarah Silverman, and Margaret Cho, television personalities Kelly Osbourne and RuPaul, as well as YouTubers Jenna Mourey (Jenna "Marbles"), Grace Helbig ("itsgrace") and Justine Ezarik ("iJustine").

Other guests included Russell Peters, Gary Busey, Rob Delaney, Gabriel Iglesias, Carmen Electra, Lance Bass, Howie Mandel, Chris Hardwick, Bill Engvall, Tom Green, Penn Jillette, Aisha Tyler, Anthony Jeselnik, Eric André, Theo Von, Nick Kroll and T.J.

[9] In 2003, Rivers appeared in a PETA anti-fur ad campaign, encouraging consumers to "Fake It...for the Animals' Sake.

She was fired in the episode that aired April 26, 2009, after which she stormed out of the boardroom, verbally assaulted teammates Annie Duke and Brande Roderick, yelled at the production crew, and refused the obligatory exit interview.

Her mother was also a contestant on that season of The Apprentice, and threatened to quit the show after Melissa's firing, but remained and ultimately won the competition.

[14] Rivers married horse trainer John Endicott in December 1998, at New York City's Plaza Hotel in a $3 million wedding.

[19] In January 2015, Rivers filed a malpractice lawsuit against the clinic and doctors who performed surgery on her mother that caused her death.

[21] In 2022 Rivers met attorney Steve Mitchel at a Didi Hirsch Mental Health and Suicide Prevention event.