GWR's hourly Portsmouth Harbour-Cardiff Central services are sometimes diverted via Melksham to terminate and start at Swindon rather than Cardiff when engineering work is taking place between Bath, Bristol and the Severn Tunnel in connection with the electrification of the Great Western main line.

A number of Mendip Rail aggregate trains from the quarries at Merehead and Whatley also use the line, serving destinations such as Appleford, Oxford Banbury Road, Wootton Bassett and Acton (London).

A train of empty ballast hoppers operated by GB Railfreight runs most weekdays from Westbury via Melksham to Cliffe Hill Stud Farm in Leicestershire.

An additional 20 free car parking spaces were provided at the same time, together with covered cycle accommodation, CCTV and a new passenger shelter.

As of 2020, there is a "next train" digital display on the station platform as well as a more detailed arrivals and departures screen in the adjoining car park.

[23] With Melksham being served by trains on the Swindon to Westbury route it comes under the remit of the TransWilts Community Interest Company (CIC) which is accredited by the Department for Transport.

[24] As part of its Melksham Masterplan it is turning a disused building outside the station into a Hub including a café with toilets, cycle hire and EV charging points.