Membrane estrogen receptor

[15][16] Gq-coupled mERs (Gq-mERs) activation has been demonstrated to rapidly increase membrane excitability various neuronal cell types by desensitizing GABAB receptor coupling to G protein-coupled inwardly rectifying K+ channels (GIRKs).

[17][18][19] Localization of mERs in caveolae allows them to be held in close proximity to specific receptors such as mGluRs.

[20] Various studies have demonstrated mER's ability to activate mGluR signaling, even in the absence of glutamate.

[25][26] GPER1 pathways modify local inflammation and strengthen cellular immune responses in breast cancer and melanoma, making it a strong prognostic marker.

[34] In neural reward circuity, nuclear ERs are not commonly expressed, and mERs have been demonstrated to act on mGluR5 to facilitate psychostimulant-induced behavioral and neurochemical effects.