Mende's abundant lumber resources and possession of silver, gold and lead mines led to its rapid development.
From the 6th century BC, it was one of the cities that controlled trade routes along the coast of Thrace; there were even confirmed dealings with the Greek colonies in Italy, especially concerning the export of the famous local wine Mendaeos oinos.
During the 5th century BC, Mende became one of the most important allies of Athens and joined the Delian League, paying a tax that varied from six up to fifteen Attic talents per year.
During the Peloponnesian War, Mende, Toroni and Skione were the main regional goals of the two combatants, Athens and Sparta, specially after Brasidas, the Spartan general, raised an army of allies and helots and went for the sources of Athenian power in north Greece in 424.
The acropolis of the city is located to the south uppermost point of the hill, where large storage buildings among with pottery dated from the 11th to the 4th century, were found.