[15] The Mentha species in general demonstrate a large amount of genetic variation and ease of hybridization, which has made taxonomic distinctions a fraught question.

[16][17] In a 2018 analysis, samples of M. royleana from different geographic regions of Pakistan demonstrated the greatest amount of genetic variability among the studied Mentha species.

[21] Studies of populations of M. royleana and M. spicata determined they were genetically distinct enough to justify their separate species classifications.

[22] Recent literature continues to call for further investigation to establish M. royleana's true taxonomic status.

[23][17] While Mentha royleana's native distribution is in the region of the Himalayas (including India, Pakistan and Nepal), it is now established throughout Northwest Asia and Europe.

[27][3][28] In the Margalla Hills, part of the Himalayan foothills, it is ground with the fruit of Zanthoxylum armatum and combined with salt as a stomach ache cure.

[7] Herbal medicine practitioners in Batakundi mixes the leaves of M. royleana into green teas, with cooling and gas relief properties.

[10] In the Haramosh valley in Gilgit District, M. royleana is combined with pomegranate, ginger and garlic to produce a juice intended to treat diabetes and heart issues.

[29] Combined with Thymus linearis (Himalayan Thyme), it is used to treat high blood pressure and abdominal worms.