[6] The engine is a detuned version of the M177 V8 Biturbo found in the Mercedes-AMG GLS 63 4MATIC+, but with a 48-Volt mild hybrid system.

[7][8] The GLS 600 4MATIC isn't based on the Mercedes-Maybach Vision Ultimate Luxury concept vehicle shown at 2018 Shanghai Motor Show.

[9] This version is the first time that a three-point star stand-up ornament affixed to the hood/bonnet on an SUV, rather than the large "jet-engine" three-point star filling up the grille space as found in every SUV from Mercedes-Benz since 1979.The second generation AMG version of the GLS-Class, GLS 63 4MATIC+, was introduced at the same time as Mercedes-Maybach GLS 600 4MATIC.

The novel feature is the "reintroduction" of classical AMG monoblock alloy wheels, which were popular option in the 1980s and 1990s.

[11] In March 2024, Mercedes-Benz recalled over 116,000 GLE and GLS cars, built from 2019 to 2024, due to a loose 48-volt ground cable that may not have been tightened properly during assembly.