Mercedes College is an independent Roman Catholic single-sex secondary day school for girls, located in the Perth central business district, Western Australia.

The school has its beginnings in the landing at the Swan River Colony of Irish Sisters of Mercy.

[2] Led by Sister Ursula Frayne, they founded the first Catholic school in the colony on 2 February 1846[3] beginning their teaching with just one pupil.

[2] Classes were conducted in a rented St Georges Terrace cottage, near Victoria Avenue.

Enrolment grew to 100 by the end of 1846, by which time the school had moved to permanent accommodation at Victoria Square.