It had moved to a building at Wabash and Van Buren Streets in the later-named Loop or Central business district of Chicago.

Then-Mayor Richard J. Daley aided the hospital in acquiring the site so that it continued to serve the city of Chicago.

The last year data were made available, Mercy Hospital and Medical Center had 16,359 admissions, 2,186 inpatient procedures, 3,973 outpatient surgeries, and its emergency department had 52,692 visits.

[1] In June 2016, a woman filed complaints with the appropriate federal and state agencies against Mercy Hospital and Medical Center, for refusing to treat her although she was bleeding, cramping, and in pain after her IUD dislodged.

The hospital follows policies set out by the United States Conference of Catholic Bishops as to limitations on medical care in conformance with their religious beliefs.

Mercy Hospital stated that their protocol in caring for a woman with a dislodged or troublesome IUD would be to remove it, and that the doctor bore the responsibility for her refusal to administer the recommended medical treatment.

[11] Insight, a clinical technology company,[12] has been the owner of Mercy Hospital and Medical Center since June 1, 2021.