Mescherin is a municipality in the Uckermark district, in Brandenburg, in north-eastern Germany.

A road bridge links Mescherin with the Polish-Pomeranian town of Gryfino across the river.

Mescherin is located on the northern edge of Lower Oder Valley National Park.

In Rosow, a 13th-century church serves as a joint German-Polish memorial site for the flight and expulsion of Germans during and after World War II and the resettlement of Poles from Soviet-annexed eastern Polish territory into former eastern German provinces which became again Polish in 1945.

Rosow was chosen as the Pomeranian village became a border checkpoint of both the federal highway Bundesstraße 2 and the Berlin-Szczecin railway.