Prenzlau (German: [ˈpʁɛnt͡slaʊ] ⓘ, formerly also Prenzlow) is a town in Brandenburg, Germany, the administrative seat of Uckermark District.

Settled since Neolithic times, the Prenzlau area from the 7th century AD was the site of several gords erected by the Polabian Slavs called Ukrani.

When Duke Barnim signed the Treaty of Landin with the Ascanian margraves of Brandenburg in 1250, Prenzlau was already a fortified town with walls and moats, four parish churches and a monastery.

In the mid 19th century, several citizens emigrated to Australia, where they founded the town of Prenzlau, Queensland west of Brisbane.

In World War II the Oflag II-A prisoner-of-war camp was located just south of Prenzlau on the main road to Berlin.