Mese District (Burmese: မယ်စဲ့ ခရိုင်) is the district of Kayah State, Myanmar.

Its principal town is Mese.

This district borders Mae Hong Son Province of Thailand and has an open border trading station.

[1] The townships, cities, towns that are included in Mese District are as follows:[2] On April 30, 2022, new districts were expanded and organized.

Mese Township from Bawlakhe District is promoted as a district.