Ras Mesfin Sileshi (Amharic: መስፍን ስለሺ; 5 July 1905 – 23 November 1974) was an Ethiopian Major General and politician.

His father was Dejazmach Sileshi Woldesemayat and his mother was Woyzero Askale Garedew.

In 1955 he joined the cabinet as Minister of Interior, serving until 1957, when he was appointed Vice-Governor-General of Shewa.

Ras Mesfin was enormously wealthy and widely considered the largest individual landowner in Ethiopia, and his estates were claimed to reach up to 50,000 gashas (2,000,000 ha) in Illubabor and Kaffa alone, in addition to large estates in Shewa and Hararghe.

[3] He was arrested by the Derg in August 1974 during the "creeping coup" and was among those summarily executed in the Massacre of the Sixty.