It serves all high school students in the RSU 18 school unit, which includes Oakland, Sidney, Belgrade, China and Rome.

The campus features an 826-seat performing arts center that was built for the school in 1993.

[4] In 2005, the district dedicated the Performing Arts Center to former superintendent J. Duke Albanese.

Messalonskee is a member of the Kennebec Valley Athletic Conference.

Notable alumni include: Nick Mayo (American pro basketball player), Dylan Gagne (Analyst for S&P), and Will McPherson (singer/songwriter).