At the end, the main stream spreads over the coastal plain of Chrysoupolis and expands as a deltaic system with freshwater lakes and ponds forming the Nestos delta.

In the Geography of Claudius Ptolemy, the river is referred to as Nestus (Νέστος), and is said to form the boundary between ancient Macedonia and Thrace.

[3] Because of its flow between canyons and inaccessible mountain areas, Nestos was not navigable in antiquity and also did not offer a natural terrestrial road along the riverbed.

Concerning the horizontal communication from the East to the West, the river had only two passes, one in the middle and the other in the lower watercourse, which were controlled respectively by the cities of Nicopolis and Topeiros.

Finally, Nestos played an important role in the urban and economic history of the inhabitants of the estuary, where the city of Abdera and later Topeiros, founded by the Emperor Trajan.