The Dospat (Bulgarian: Доспат; Greek: Δεσπάτης, Despatis) is a river in the Western Rhodope Mountains, the most important tributary of the Mesta.

It takes its source from the 1643-metre-high Rozov vrah ("Rose Peak") in Bulgaria and flows southeast until Dospat Dam, after which it turns southwest to continue generally to the south and flow into the Mesta as a left tributary near the village Mikrokleisoura on Greek territory just south of the Greek-Bulgarian border.

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