Metcalfe is a town in Washington County, Mississippi, United States.

The county is located on the western border of the state, with the Mississippi River on the west.

According to the United States Census Bureau, the town has a total area of 1.0 square mile (2.6 km2), all land.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.

[4] As of the 2020 United States Census, there were 816 people, 351 households, and 201 families residing in the town.