Methylepitiostanol, known by the nicknames Epistane, Hemapolin, Havoc, and Epi Plex, is a synthetic and orally active anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was first described in the literature in 1974 but was never marketed for medical use.

[1][2][3] It is the 17α-methylated derivative of epitiostanol, an AAS and antiestrogen which was formerly used in the treatment of breast cancer in Japan.

[1][2] Similarly to mepitiostane, methylepitiostanol is an orally active variant of epitiostanol.

[1][2] Due to its C17α methyl group, the drug is considered to have a high potential for hepatotoxicity.

[1] Methylepitiostanol surfaced on the internet as a novel designer steroid in dietary supplements around 2009.