[5] It has been also observed that use lanthanides as a cofactor to increase its methanol dehydrogenase activity[6][7] After isolation from soil, M. extorquens was found to have a single chromosome measuring 5.71-Mb.

[12] The ability to use methanol as both a carbon and energy source was show to be advantageous when colonizing Medicago truncatula.

[13] H4MPT-dependent formaldehyde oxidation was first isolated in M. extroquens AM1 and has been used to define if an organism is utilizing methylotrophic metabolism.

[10] Many bacteria within the family Methylobacteriaceae live in different biotic environments such as soils, dust, and plant leaves.

[14] Some of these bacteria have been found in symbiotic relationships with the plants they inhabit in which they provide fixed nitrogen or produce vitamin B12.