The service operates several hospitals, dental facilities, and community health services in Brisbane and the surrounds, including the Royal Brisbane and Women's Hospital and The Prince Charles Hospital, and covers the area north of the Brisbane River through to Kilcoy.

[6] RBWH provides specialist inpatient and outpatient services in all major specialities, including cancer care and maternity, as well as state-wide emergency and trauma services.

As the state tertiary referral hospital, RBWH accounts for approximately 10% of all public hospital services in Queensland and provides services to patients from New South Wales and the Northern Territory where they are not available locally.

[7] From 1 October 2022 to 1 January 2023, RBWH provided 145,126 specialist outpatient appointments, saw 21,952 patients through the Emergency and Trauma Centre, and performed 2,724 elective surgery procedures.

Aspley Community Centre does not provide health services anymore, and instead houses the Central Patient Intake Unit.