Guest speakers have included Thomas Hopko, Frederica Mathewes-Green, Robert F. Taft, Timothy Kelleher, Sr. Vassa Larin, Myroslaw Tataryn, Suzette Phillips, Martha Shepherd, and John Behr.

[6] The institute's Byzantine Rite Chapel of St. Sophia and Her Daughters, Faith, Hope and Love, holds services in English, French, Ukrainian, and other languages such as Greek and Church Slavonic.

Other material published by the Sheptytsky Institute include DVDs and CDs for instruction in congregational singing and recordings of plenary sessions from the Study Days.

[15] The institute organized the conference "The Vatican II (Second Vatican Council) Decree on the Eastern Catholic Churches, Orientalium ecclesiarum - Fifty Years Later" featuring presentations by Brian E. Daley, John H. Erickson, Bishop Nicholas Samra, Thomas Bird, Roman Zaviyskyy, Bishop David Motiuk, Jaroslav Skira, Andriy Chirovsky, Peter Galadza and many other speakers.

[16] In November 2014, the institute organized "Religion in the Ukrainian Public Square: An Analysis of the Euromaidan and Its Aftermath" featuring presentations by Cyril Hovorun, Igor Shchupak, George Weigel, Victor Ostapchuk and others.

[17] Guest lecturers and speakers at the institute have included the renowned Greek Orthodox Theologian Dr. Kyriaki Karidoyanes Fitzgerald,[18] James Payton, Michael Jackson Bonner, Daniel Galadza, Msgr.