Meullín-Puye Nature Sanctuary is a protected area in Aysén Region of southern Chile.

[1] The sanctuary is in the basin of the Cuervo River, and protects an expanse of primary Valdivian temperate rain forest, along with lakes, wetlands and grasslands.

The predominant shrub is ñirre (Nothofagus antarctica), and the sanctuary is home to 13% of Chile's population of the species.

These include the Magellanic woodpecker (Campephilus magellanicus), Magellanic snipe (Gallinago magellanica), peregrine falcon (Falco peregrinus), southern pudú (Pudu puda), southern river otter (Lontra provocax), and Darwin's frog (Rhinoderma darwinii).

The native fish puye grande (Galaxias platei) inhabits the rivers and streams of the sanctuary.