The road is primarily operated by Caminos y Puentes Federales, which charges cars 520 pesos to travel Highway 150D,[4] with one segment in the Puebla metropolitan area built and maintained by OHL and PINFRA.

[5] The Puebla second deck opened in 2016, costing 10.5 billion pesos; the lower level is to be converted into a state-operated road with traffic lights.

The terrain rises east of Ixtapaluca and, just after its interchange serving Río Frío de Juárez, Highway 150D enters the state of Puebla.

Mexican Federal Highway 140D connects Puebla to Xalapa, the capital of the state of Veracruz, while Mexican Federal Highway 129 offers access to Amozoc de Mota, Teziutlán and Tlapacoyan and Martínez de la Torre in Veracruz.

Highway 150D enters rugged terrain in western Veracruz, passing through Cañón del Río Blanco National Park [es].

[10] East of the interchange at Maltrata, Highway 150D straightens out and enters the area of Ciudad Mendoza, Nogales, Orizaba and Córdoba.

It meets Mexican Federal Highway 180 northwest of Paso del Toro, which gives its name to the last toll booth on the road.