Federal Highway 180 is a Mexican Federal Highway that follows Mexico's Gulf and Caribbean Coast from the Mexico–United States border at Brownsville, Texas, into Matamoros, Tamaulipas, to the resort city of Cancún, Quintana Roo, in the Yucatán Peninsula.

The highway is briefly interrupted from El Encinal to Soto la Marina in Tamaulipas just north of Tampico.

The highway goes through Tampico south, interrupted briefly from Cerro Azul to Potrero del Llano, to the city of Poza Rica.

Route 77) starts the northern terminus of Highway 180 in Brownsville, Texas, at the Veterans International Bridge on the border.

After crossing the bridge into the United States, Federal Highway 180 continues as U.S. Route 83 in Brownsville which then runs northward to the U.S. highway's northern terminus, north of Westhope, North Dakota, at the Canada–United States border.