It connects southern Veracruz to Mexican Federal Highway 150D, continuing the other road's east-west trajectory.

The road is operated by Caminos y Puentes Federales, who charges a toll of 183 pesos per car to travel Highway 145D.

The route designation ends at the interchange with Mexican Federal Highway 185 serving Cosoleacaque and Minatitlán.

The 34 kilometres (21 mi) Cosoleacaque-Nuevo Teapa stretch of Highway 180D continues the west-east routing past Minatitlán and the Coatzacoalcos River toward Nuevo Teapa.

Grupo Mexicano de Desarrollo built the highway and operated it until 1998.