While the main line of US 77 passes through Victoria, Alternate US 77 veers to the west to serve Yoakum and Cuero.

A section of US 77 located in the Giddings, Texas area is known as the Martin Luther King Jr. Memorial Highway.

Between the US 40 junction and the Cowley County line is designated as a Blue Star Memorial Highway.

[2] In Nebraska, US 77 is a major north–south artery connecting the capital city of Lincoln with outlying areas to the north and south.

US 275 and NE 91 separate from US 77 just south of Winslow, and US 77 continues north as a two-lane highway until it meets US 75 at Winnebago.

After crossing the Missouri River via the Veteran's Bridge at Sioux City, the highway ends at a diamond interchange with I-29.

The segment between Milbank and Ortonville was decommissioned in 1966;[4] the remaining South Dakota portion along with most of the highway's length in Iowa section was removed in October 1981.

[5] Portions of the old highway in the Sioux Falls, South Dakota area exist today as South Dakota Highway 115, and further north, as Moody County Road 77 and Brookings County Road 77.