Federal Highway 281 (Carretera Federal 281) is a Federal Highway of Mexico, located entirely within the state of Yucatán.

It connects Celestún to Mérida, with a 23.2-kilometre (14.4 mi) spur from Hunucmá to Sisal.

[2] Within Mérida, the street is known as Avenida Jacinto Canek.

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