According to folk etymology, the original pre-Hispanic name of the village was purportedly Masicu or Maca-sicu, which the Spaniards spelled as "México".

A lavish church made of stone and tiles, the Parish of Santa Monica, was built in 1581 with Masangsang and Matúlid serving as its visitas.

In Mexico, the biggest Spanish era colonial architecture composite construction is the Lazatin-Henson-Katigbak Mansion along 2nd street, Barangay Parian (Poblacion).

[14] The Spanish colonial authorities stripped México of its political importance after the Pampanga Revolt by moving the provincial capital further downstream to Bacolor.

By the 18th century, the Chinese traders and their mestizo de sangley descendants living in México, Guagua and Malabon had formed and maintained business and social alliances with each other.

[citation needed] In 1898, General Maximino Hizon, rallied Kapampángans to fight the Spanish Colonial forces under Emilio Aguinaldo's revolutionary banner and ordered the execution of the Parish priests of México and San Fernando.

When the Americans replaced the Spaniards as the new colonists, General Maximino Hizon soon rose up to become supreme commander of all the Philippine Forces in Pampanga.