Qualification for the Little League World Series in Mexico, whereby teams based in Mexico compete to select a champion to participate in the Little League World Series (LLWS), has occurred since 2001.

Mexican teams have won three LLWS championships (1957, 1958, 1997) and have been runner-up three times (1964, 1985, 2008).

The table below lists the records of teams from Mexico that have competed in the LLWS in South Williamsport, Pennsylvania.

Participation before 2001 was inconsistent (for example, only one appearance during the 1970s), as teams from Mexico had to qualify via the Latin America Region.

Notably, teams from Mexico have twice represented regions of the United States in the LLWS: As of the 2024 Little League World Series.