On 7 November 2021, 19 people were killed in a large crash on the Mexican Federal Highway.

[2] A shampoo truck smashed into cars at a toll booth on the highway connecting Mexico City with Puebla, causing a large fire.

[3][4] A truck travelling towards Mexico City crashed through the San Marcos Huixtoco tollbooths before colliding with many cars heading in the opposite direction.

[5] The crash precipitated a large fire that engulfed several vehicles and burned their occupants to death.

[8][9] Mexico's Federal Roads and Bridges and Related Services agency said the crash was caused by a brake failure.