Mexilhoeira Grande (European Portuguese pronunciation: [mɨʃiʎuˈɐjɾɐ ˈɣɾɐ̃dɨ]) is a civil parish in the municipality (concelho) of Portimão in the southern Portuguese region of the Algarve.

[2] Mexilhoeira Grande is situated in the north of the municipality of Portimão, primarily encompassing rural lands comprising white-painted homes, traditionally agricultural in character.

It is bordered in the north by Monchique, by Portimão in the east, Alvor to the south, and by the parishes of Odiáxere, Bensafrim and Marmelete, in the north and northwest, respectively.

The region's economy is primarily agricultural-based, although tourism has an important influence on local revenues.

The Autódromo Internacional do Algarve, is the natural gateway to the region; situated in an area of plains, approximately 6 kilometres (3.7 mi) to the north of the parish, it is interconnected by variants of the Estrada Nacional EN125.