[5] Mezzojuso borders the following municipalities: Campofelice di Fitalia, Cefalà Diana, Ciminna, Godrano, Marineo, Villafrati.

Mezzojuso means in Arabic: “Manzil Yusuf” (منزل يوسف) which translates in English to “Houses or 'hamlet' of Joseph.

The town and all the neighboring area was granted by the Norman king Roger (Ruggerio) II, to the Monastery of Saint John the Hermit, of Palermo in 1132.

With a contract of 1501 with the Palermo religious authorities, they undertook the restoration of the church, the donation of olive oil and wax and everything needed for the rituals that had to be executed according to the Byzantine rite by priests.

The most significant local event happens before Easter, with the "Mastru Campu" ("maestro di campo" in Italian) which takes place on the last Sunday of Carnival, just before the start of Lent.