Palazzo Adriano (IPA: [pa'latʦo adriˈano], Arbëreshë Albanian: Pallaci,[3] Sicilian: U Palàzzu[4]) is a town and comune of Arbëresh origin in the Metropolitan City of Palermo, Sicily, southern Italy.

Located in the heart of Sicania on the northern slopes of Monte delle Rose, almost equidistant from Palermo and Agrigento, it is a town of Arbëreshë origin.

From 1282, the fiefs land holdings that now constitute the area of Palazzo Adriano saw more than thirty baronies granted leases by the abbots of the monastery of Santa Maria di Fossanova.

In 1787, the Royal Court of Ferdinand IV of Naples captured all these land holdings, which fell under the control of Palermo.

Starting in the 15th century, a group of Albanians, the Arbëreshë, settled in the sparsely populated areas around Palazzo Adriano.