Archaeologically the village constitutes a valid chronological guide for local production of objects from the first native societies to the relationship with the first Greek settlers during the great season of the apoikiai during the 8th - 7th century BC.

Four gold and silver bowls dating from 650 to 600 BC were found in a tomb in the vicinity of the village in the 18th century, by Paolo Orsi.

[5] The Archeological Museum of Agrigento, adjacent to the Valley of the Temples, holds a selection of vases found in the vicinity of the village, mainly inside tombs.

In 1600, the barony was acquired by the Princes of Castelvetrano, D'Aragona and Tagliavia and finally came under the jurisdiction of Pignatelli, Dukes of Monteleone, who kept it until 1812, when feudalism was suppressed in Sicily.

Sant'Angelo Muxaro borders the following municipalities: Agrigento, Alessandria della Rocca, Aragona, Casteltermini, Cattolica Eraclea, Cianciana, Raffadali, San Biagio Platani, Santa Elisabetta.