Along with fellow comedian Charlie Pickering, Chamberlin was a co-creator of Melbourne comedy room Stagetime.
In 2002, Chamberlin joined forces with Charlie Pickering, winning the comedians' choice Piece of Wood Award for their show Boiling Point.
He appeared in the Melbourne Comedy Festival in 2005 with his show There's A Party At Stefan Edberg's Place,[4] and in 2006 with Michael Chamberlin & the Ten Commandments.
[5] Chamberlin was also a core cast member and writer for the Australian sketch comedy television show skitHOUSE[5] from 2003 - 2004.
In 2008, Chamberlin co-hosted Foxtel's TV series The Mansion with Charlie Pickering.