He played college football for the LSU Tigers and was selected by the Tampa Bay Buccaneers 15th overall in the 2004 NFL draft.

Clayton prepped at Christian Life Academy in Baton Rouge where he was one of the most sought after recruits in the nation during his senior year.

He played in the first ever U.S. Army All-American Bowl on December 30, 2000, alongside fellow LSU teammates Ben Wilkerson, Andrew Whitworth, and Marcus Spears.

[2] Clayton played college football at Louisiana State University, where he was part of the NCAA champion LSU Tigers in 2003.

With knee surgery in the offseason and a season riddled with small mistakes on the field, he finished with 32 receptions for a total of 372 yards and no touchdowns.

He was forced to sit out the final game of the regular season against the New Orleans Saints with a turf toe injury, and also sat out the Buccaneers playoff match-up against the Washington Redskins.

His touchdown, thrown by Bruce Gradkowski, came with seconds left and gave the Tampa Bay Buccaneers the go ahead lead for their first win of the 2006 season.

[10][11] The move also reunited Clayton with Giants quarterback Eli Manning with whom he shared a dorm during the NFL combine in 2004.

His cousin, Noah Cain, played football at Penn State and LSU and signed as an undrafted free agent for the Cincinnati Bengals.