Lulume Bayiga attended St. Paul's Boys Primary School in Nkokonjeru, for his elementary education.

[2] In 1997, he began to work at "Nsambya General Clinic", a private medical practice, as the Deputy Director, a position he still holds today.

That same year, he was elected executive director of the Uganda Medical Volunteers' Association, an NGO, a position he still serves in today.

He first entered politics in 2006 when he unsuccessfully contested for the Buikwe County South constituency seat against one Anthony Mukasa of the National Resistance Movement (NRM) party.

[3] In the by-elections held in May 2008, Bayigga trounced his opponent and was sworn in as the Member of Parliament (MP) for the constituency on Wednesday May 7, 2007.