It is within Nakawa Division, an administrative borough of Kampala, Uganda's capital city.

Kyambogo sits on Banda Hill, which rises to an altitude of 1,240 metres (4,070 ft), above sea level.

The neighborhood is bordered by Kiwatule to the north, Banda to the east, Kinnawattaka to the southeast, Mbuya to the south, Nakawa to the southwest, Ntinda to the west and northwest.

The location of the neighborhood is approximately 10 kilometres (6.2 mi), by road, east of Kampala's central business district.

In 1948, the Institute of Teacher Education Kyambogo (ITEK) was established.