He is the George and Ruby deStevens Professor and Head of the Laboratory of Cellular and Structural Biology at The Rockefeller University,[1] as well as the Director of the National Center for Dynamic Interactome Research (NCDIR).

He then conducted research as a Jane Coffin Childs Postdoctoral Fellow from 1990 to 1993 at The Rockefeller University with his supervisor Günter Blobel, focusing on the isolation and characterization of the yeast NPC.

This revealed its organizational framework, incorporating robust columns, flexible connector cables, and inwardly directed anchors crucial for RNA and protein transport.

[16] He also provided a comprehensive classification of the molecular components of the yeast NPC, mapping its architecture and suggesting a virtual gating mechanism for nucleocytoplasmic transport.

Of note, he has helped develop pipelines to generate nanobodies, small robust single domain antibodies derived from camelids that can be targeted with high specificity against almost any antigen.