He entered a Lexus-powered Doran JE4 in 12 races with primary drivers Ozz Negri and Burt Frisselle, finishing second at Watkins Glen's short course and third at Homestead-Miami Speedway.

Negri and Mark Patterson completed the season, with a best finish of third at Watkins Glen, while Mears and Mike Borkowski earned podiums at California Speedway and Barber Motorsports Park.

Shank was the first team owner to step up to the second generation DP in 2008, upgrading both of his cars to Ford-powered Rileys—with Negri validating his move by winning the pole for that year's Rolex 24 at Daytona.

Meyer Shank Racing ran a single Riley Ford Ecoboost DP with drivers John Pew and Oswaldo Negri in the new series.

In 2016 the team claimed wins at Laguna Seca and Petit Le Mans with Ozz Negri and John Pew behind the wheel at both tracks.

Operating for the past two seasons as a customer team fielding a Honda-powered Ligier chassis in IMSA's prototype division, Michael Shank Racing has been a consistent front-runner in the headline category of the WeatherTech SportsCar Championship.

The Columbus, Ohio-based operation will run a pair of Acura NSX GT3s in the GTD class of the endurance racing series.The team switched to the GT Daytona (GTD) class in 2017 and entered two factory-backed Acura NSX GT3s with drivers Oswaldo Negri Jr, Jeff Segal, Andy Lally and Katherine Legge.

The following year, 2022, was a big season for Meyer Shank Racing as the team saw their first victory at the Rolex 24 in Daytona with drivers Oliver Jarvis, Tom Blomqvist, Hélio Castroneves, and Simon Pagenaud.

However, after the race, the team and drivers were penalized all the points and prize money, due to infringement on the rules concerning tire pressure.

The original intention for the IndyCar program was to run under the name "MSR Indy", with A. J. Allmendinger and Brian Bailey as co-owners.

MSR announced that it had sold its Dallara chassis to Sam Schmidt Motorsports in February 2013 and declared its intention to collaborate with another team on a 2013 Indianapolis 500 entry.

For the 2017 Indianapolis 500, the team partnered with Andretti Autosport for an entry driven by Jack Harvey.In the 2018 IndyCar Series, in a partnership with Schmidt Peterson Motorsports, the team entered Jack Harvey in 6 events, including the 2018 Indianapolis 500, and in 2019 in 10 races, obtaining the first podium, the 3rd place in the IndyCar Grand Prix.