A great deal of McGuire's published work in the last several years have been attempts to expand the application of Darwinian or evolutionary biology principles to areas such as law, healthcare, psychiatry and human behavior.
A significant amount of McGuire's work in the last few decades was to position developments in biology and evolutionary theory as tools to improve our understanding of politics, economics, and law.
"[O]ur unimpressive record of understanding and forecasting political, social and economic events is largely a consequence of the failure to incorporate human nature into our thinking.
These and other scientific advances, McGuire writes, provide more exact information about human behavior, which in turn "facilitates a better understanding of which policies and decisions are likely to be effective.
Wilson posited that using the same tools and reasoning as had been applied to animal and nonhuman primate studies, we could identify and utilize the evolutionarily origins of human social organization, barter and reciprocation, bonding, role playing, communication, culture, ritual and religion.
McGuire & Troisi build a case for Darwinian Psychiatry as a science of human behavior, then offer evolutionary models of mental conditions including depression, personality disorders, schizophrenia, phobias, anorexia nervosa, suicide and others.