Watkins has also had recurring roles on other television series, such as The New Adventures of Old Christine, Catastrophe, Enlightened and Search Party and appeared in films such as The Back-up Plan (2010), Wanderlust (2012), Enough Said (2013) and Sword of Trust (2019).

[8] She lived there from 1996 to 2000 and appeared onstage with Portland Center Stage and the defunct improv group Toad City Productions.

However, while SNL was on summer hiatus, the news broke in early September 2009 that Watkins, along with fellow castmate Casey Wilson, were both to be let go from the show[18][19] and would not be returning for the 2009–10 season.

Watkins also starred alongside Malin Åkerman, Bradley Whitford, and Marcia Gay Harden in the short-lived, but well-received[22] ABC sitcom Trophy Wife.

Watkins co-created (with writing partner and fellow Groundling, Damon Jones)[28] the short-lived 2014 USA Network comedy series Benched.

[31] Watkins has appeared in supporting roles in films such as Enough Said, In a World...,[32] Afternoon Delight, The Back-Up Plan, Wanderlust, They Came Together and Lazy Eye.

[33][34] Watkins is married to Fred Kramer, who is a founding partner of Reason Ventures and General Manager of Critical Mass Studios, Inc.[35] Kramer used to be Executive Director of the Jewish World Watch organization, a Los Angeles-based anti-genocide non-profit, focused on the situations in Sudan and Congo.