In 2007, the team Olympiacos made an offer for Sifakis, which was accepted by OFI, and he played as a replacement of the national goalkeeper Antonis Nikopolidis.

In the season 2010–2011 he passed the group stage of the Europa League with Aris and were then eliminated by Manchester City of Roberto Mancini, at Round of 32 of the competition.

[3][4] Newly promoted Jupiler Pro League side Charleroi are set to sign Michalis Sifakis on a free transfer after the Greek 'keeper severed ties with Aris at the end of last season.

[6] In his first interview as a member of the club, he stated that "Atromitos is one of the few teams for which I would have returned to Greece and it is true that only a few days ago I wasn’t even considering it".

[8] On 12 September 2014, Sifakis penned a one-year deal with fellow Super League Greece side Levadiakos.

Sifakis, who played for Charleroi during the 2012–2013 season, will have a Greek teammate, as Thanasis Papazoglou has also joined Kortrijk.

Michalis Sifakis made his Belgium Jupiler League debut for Kortrijk on 2 April 2016 in a scoreless draw at home to Royal Mouscron-Péruwelz.

[14][15] On 10 December 2017, Michalis Sifakis made his league debut for Samsunspor, keeping a clean sheet in a 0–0 draw away to Denizlispor.

Under coach Fernando Santos, Sifakis played most of his country's UEFA Euro 2012 qualifying matches.

Following an injury to regular goalkeeper Kostas Chalkias in Greece' second game of Euro 2012, against the Czech Republic, Sifakis was substituted into the game to replace him and he remained the starting goalkeeper for the rest of the tournament, as Greece reached the Quarter finals of the competition.