Among his earliest works is the design of the new National Museum of Archaeology and Ethnography GA Sanna in Sassari, which he created with his father, Carlo.

Famous members of the family include Clemente Busiri Vici (1887–1965), who designed churches for Pope Pius XI, such as Gran Madre di Dio and San Roberto Bellarmino, both in Rome.

Andrea and his brothers also worked on a variety of projects for the Fascist hierarchy, including the design for the Istituto Luce, a propaganda arm for the state.

Clemente also helped design villas for prominent members of the Fascist leadership including the Maresciallo Pietro Badoglio.

It was here that he developed a personal style ("Mediterranean architecture"), characterized by soft, whitewashed walls and fixtures painted in the colour now known as 'Busiris Green'.

As an urban architect he contributed to the redevelopment of Athens and Rome, where his distinctive buildings remain, many with windows still painted Busiris Green, in the Via Vigna Stelluti, Ponte Milvio and Parioli areas.

Developing the 'Mediterranean' style of architecture he had already tested on the Pontine Marshes area, Vici adopted even softer, organic forms, almost always coated with whitewash, and repeating decorative elements such as chimneys, arches, triangular slits, Mediterranean terracotta tiles and ceramics.

Further north along the eastern coast of Sardinia, at Porto Rafael opposite the archipelago of La Madalena, Vici designed the Piazzetta, a chapel, and numerous private villas, for instance for the Ward and Brandolini families, during the course of the 1960s.