Later versions were available with an InPort ISA interface, requiring a Microsoft bus card to be installed in the computer or a DE-9 serial connector.

[6][7][5] In 1985, Microsoft introduced the "gray-eyed" Microsoft Mouse, featuring a higher resolution than competing mice, and a rebadged copy of ZSoft PC Paintbrush called “PC Paintbrush,” which replaced Doodle in version 4 of the drivers.

In 1987 the "dove bar" Microsoft Mouse (so called for the curved palm rest's resemblance to a Dove soap bar) was introduced, in variants for both Microsoft's InPort, serial port and PS/2 port.

The "kidney" Microsoft Mouse 2.0 was introduced in 1993, and its design served as the basis for the IntelliMouse, which debuted in 1996.

In January 2024, Microsoft announced that it would license the design and manufacturing of its current mice products to Incase, as part of an effort to focus more on its Surface-branded accessories.