It was created in 1991 by Richard Rashid,[2] Bill Gates and Nathan Myhrvold with the intent to advance state-of-the-art computing and solve difficult world problems through technological innovation in collaboration with academic, government, and industry researchers.

[26][27] Since 2016, Microsoft has partnered with Toyota Connected to research technology for telematics, data analytics and network security services.

[29] In 2023, Microsoft signed a multi-year deal to collaborate with Syneos Health in development of a platform to leverage machine learning for the optimization of clinical trials.

[30] Microsoft's "AI for Good" initiative represents a significant commitment to leveraging artificial intelligence technology for social and environmental benefits.

This initiative is part of a broader vision by Microsoft to utilize AI in addressing some of the world's most challenging issues, including those related to health, the environment, accessibility, cultural heritage, and humanitarian action.