It is only known to occur in a single locality along the Kızılırmak River in Turkey, where it grows parasitically on the crustose lichen Caloplaca persica.

The type specimen was collected by the second author along the Kızılırmak River (Sivas Province) at an altitude of 1,300 m (4,300 ft); there, the lichen was found growing on the apothecial discs of the crustose lichen Caloplaca persica, which itself was growing on the bark of a Populus tree.

They are apparent as barely visible blackish spots with a diameter between 30 and 50 μm, with an ostiole (opening).

Infections by this fungus do not seem to be highly pathogenic to the lichen, as the hymenium of the apothecia continues producing spores as normal.

[1] Microsphaeropsis caloplacae is only known from the type locality, a well-lit site with typical steppe vegetation, about 50 m (160 ft) from the Kızılırmak River.