[1] The museum's building was originally completed in 1982 and designed by architects E. Verner Johnson & Associates of Boston and Stuck Frier Lane Scott Beisner of Jonesboro.

In November 2011 the museum was awarded a $7.8 million capital grant from the Donald W. Reynolds Foundation for renovation of the building and exhibits.

Seating up to 50 people, the Digital Dome has surround sound, a 180-degree screen for viewing the night sky, and programming to educate children and adults about the science and history of space exploration.

[6] WDD Architects designed and built the Bob Wheeler Science Sky-walk that connects the museum to the surrounding outdoors.

32-feet high with hands-on exhibits, the structure provides a one-of-a-kind outdoor experience for guests visiting Mid-America Science Museum and was sponsored by the Hot Springs Advertising and Promotions Commission.